Review of methods for missing data

Abstract

This paper reviews methods for handling missing data in a research study. Many researchers use as hoc methods such as complete case analysis, available case analysis (pairwise deletion), or single-value imputation, though these methods are easily implemented, they require assumptions about the data that rarely hold in practice. Model-based methods such as maximum likelihood using the EM algorithm and multiple imputations hold more promise for dealing with difficulties caused by missing data. While model-based methods require specialized computer programs and assumptions about the nature of the missing data, these methods are appropriate for a wider range of situations than the more commonly used ad hoc methods. The paper provides an illustration of the methods using data from an intervention study designed to increase students' ability to control their asthma symptoms.